MolNFT v1 · #93579 · protein

Crystal structure of prethrombin-2 mutant E14EA/D14LA/E18A/S195A

4H6T · Prothrombin: “Crystal structure of prethrombin-2 mutant E14EA/D14LA/E18A/S195A”. X-ray diffraction, 1 ligand (PO4), 3 pockets (best druggability 0.52). MolNFT v1 #93579 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4H6T
Type: protein
Length: 293 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Prothrombin
EC: 3.4.21.5
UniProt: P00734
Ligands: PO4
Pockets: 3 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 17% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Prothrombin (EC 3.4.21.5)	protein	293	17% helix, 31% strand	P00734

Ligands and binding sites

PO4 · Phosphate ion · ion · 7 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	113	0.52	0.82	26	empty
2	58	0.38	0.79	13	empty
3	79	0.33	0.74	22	empty

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

4H6T · Crystal structure of prethrombin-2 mutant E14eA/D14lA/E18A/S195A · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00734
Elsewhere: RCSB PDB 4H6T · PDBe 4H6T · UniProt P00734

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.