MolNFT v1 · #93570 · protein

Crystal structure of staphylococcal complement inhibitor scin-B(4-85)

4H6H · Fibrinogen-binding protein: “Crystal structure of staphylococcal complement inhibitor scin-B(4-85)”. X-ray diffraction, 2 pockets (best druggability 0.62). MolNFT v1 #93570 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 4H6H
Type: protein
Length: 319 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fibrinogen-binding protein
UniProt: Q99UU9
Pockets: 2 · best druggability 0.62

Structure

x-ray diffraction · 2 distinct chains · 82% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fibrinogen-binding protein	protein	79	82% helix, 0% strand	Q99UU9
B, C, D	Fibrinogen-binding protein	protein	80	81% helix, 0% strand	Q99UU9

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	434	0.62	0.77	34	empty
2	171	0.45	0.75	24	empty

Interfaces

4 interfaces between chains.

A–D · 593 Å² buried · 8 hydrogen bonds · protein-protein
C–D · 302 Å² buried · 1 hydrogen bond · protein-protein
B–C · 294 Å² buried · 6 hydrogen bonds · protein-protein
B–D · 154 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

4H6H · Crystal Structure of Staphylococcal Complement Inhibitor SCIN-B(4-85) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99UU9
Elsewhere: RCSB PDB 4H6H · PDBe 4H6H · UniProt Q99UU9

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