MolNFT v1 · #93493 · protein

Structure of the salmonella plasmid virulence C protein (spvc) H106N mutant.

4H43 · 27.5 kda virulence protein: “Structure of the salmonella plasmid virulence C protein (spvc) H106N mutant.”. X-ray diffraction, 3 pockets (best druggability 0.74). MolNFT v1 #93493 on GenesisL1: 3D structure, binding sites and…

PDB: 4H43
Type: protein
Length: 428 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 27.5 kda virulence protein
UniProt: P0A2M9
Pockets: 3 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	27.5 kda virulence protein	protein	214	34% helix, 17% strand	P0A2M9

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	896	0.74	0.78	70	empty
2	60	0.47	0.84	18	empty
3	68	0.34	0.76	14	empty

Interfaces

1 interface between chains.

A–B · 1170 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

4H43 · Structure of the Salmonella plasmid virulence C protein (SpvC) H106N mutant. · the same entry in another collection · chain A against A, TM-score 1.00
P0A2M9 · AlphaFold monomer V2.0 prediction for MAPK phosphothreonine lyase (P0A2M9) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A2M9
Elsewhere: RCSB PDB 4H43 · PDBe 4H43 · UniProt P0A2M9

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