MolNFT v1 · #93421 · protein
Crystal structure and computational modeling of the Fab fragment from the protective anti-ricin monoclonal antibody RAC18
4H20 · Light chain of Fab fragment from the anti-ricin monoclonal…: “Crystal structure and computational modeling of the Fab fragment from the protective anti-ricin monoclonal…”. X-ray diffraction, 6 pockets (best druggability 0.53).…
- PDB
- 4H20
- Type
- protein
- Length
- 434 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Light chain of Fab fragment from the anti-ricin monoclonal antibody RAC18; Heavy chain of…
- Pockets
- 6 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Light chain of Fab fragment from the anti-ricin monoclonal antibody RAC18 | protein | 214 | 5% helix, 50% strand | — |
| H | Heavy chain of Fab fragment from the anti-ricin monoclonal antibody RAC18 | protein | 220 | 8% helix, 54% strand | — |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 348 | 0.53 | 0.73 | 55 | empty |
| 2 | 83 | 0.50 | 0.83 | 21 | empty |
| 3 | 99 | 0.45 | 0.79 | 19 | empty |
| 4 | 97 | 0.43 | 0.78 | 16 | empty |
| 5 | 57 | 0.32 | 0.76 | 18 | empty |
Interfaces
1 interface between chains.
- L–H · 1877 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 4H20 · Crystal Structure and Computational Modeling of the Fab Fragment from the Protective… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4H20 · PDBe 4H20
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