MolNFT v1 · #93341 · protein

Structure and interactions of the RNA-dependent RNA polymerase from bacteriophage PHI12

4GZK · RNA-dependent RNA polymerase P2: “Structure and interactions of the RNA-dependent RNA polymerase from bacteriophage PHI12”. X-ray diffraction, 1 ligand (MG), 5 pockets (best druggability 0.82). MolNFT v1 #93341 on GenesisL1: 3D…

PDB: 4GZK
Type: protein
Length: 650 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-dependent RNA polymerase P2
UniProt: Q94M06
Ligands: MG
Pockets: 5 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-dependent RNA polymerase P2	protein	650	43% helix, 16% strand	Q94M06

Ligands and binding sites

MG · Magnesium ion · metal · 5 copies · chains A
FMT · Formic acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	801	0.82	0.85	92	empty
2	393	0.74	0.84	48	empty
3	209	0.66	0.85	27	empty
4	83	0.49	0.83	19	MG
5	57	0.31	0.76	21	empty

Compared structures

4GZK · Structure and interactions of the RNA-dependent RNA polymerase from bacteriophage phi12 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q94M06
Elsewhere: RCSB PDB 4GZK · PDBe 4GZK · UniProt Q94M06

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