MolNFT v1 · #93308 · protein
The E142L mutant of the amidase from geobacillus pallidus showing the result of michael addition of acrylamide at the active site cysteine
4GYL · Aliphatic amidase: “The E142L mutant of the amidase from geobacillus pallidus showing the result of michael addition of…”. X-ray diffraction, 2 ligands (ROP, CL), 1 pocket (best druggability 0.27). MolNFT v1 #93308 on GenesisL1: 3D…
- PDB
- 4GYL
- Type
- protein
- Length
- 340 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Aliphatic amidase
- EC
- 3.5.1.4
- UniProt
- Q9L543
- Ligands
- ROP, CL
- Pockets
- 1 · best druggability 0.27
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Aliphatic amidase (EC 3.5.1.4) | protein | 340 | 33% helix, 24% strand | Q9L543 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 57 | 0.27 | 0.73 | 16 | empty |
Modifications
Observed in the structure: 1 covalent (covalent ligand).
Compared structures
- 4GYL · The E142L mutant of the amidase from Geobacillus pallidus showing the result of Michael… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9L543 · AlphaFold monomer V2.0 prediction for aliphatic amidase (Q9L543) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9L543
- Elsewhere: RCSB PDB 4GYL · PDBe 4GYL · UniProt Q9L543
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