MolNFT v1 · #93186 · protein
Structure of the arylamine N-acetyltransferase from mycobacterium abscessus
4GUZ · Probable arylamine N-acetyl transferase: “Structure of the arylamine N-acetyltransferase from mycobacterium abscessus”. X-ray diffraction, 11 pockets (best druggability 0.87). MolNFT v1 #93186 on GenesisL1: 3D structure, binding…
- PDB
- 4GUZ
- Type
- protein
- Length
- 1,136 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable arylamine N-acetyl transferase
- EC
- 2.3.1.118
- UniProt
- B1ME52
- Pockets
- 11 · best druggability 0.87
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Probable arylamine N-acetyl transferase (EC 2.3.1.118) | protein | 284 | 34% helix, 30% strand | B1ME52 |
Pockets
11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1123 | 0.87 | 0.88 | 121 | empty |
| 2 | 1107 | 0.87 | 0.88 | 120 | empty |
| 3 | 247 | 0.83 | 0.95 | 42 | empty |
| 4 | 256 | 0.64 | 0.82 | 40 | empty |
| 5 | 259 | 0.62 | 0.80 | 37 | empty |
Interfaces
5 interfaces between chains.
- A–D · 960 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 922 Ų buried · 19 hydrogen bonds · protein-protein
- C–D · 898 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 271 Ų buried · 1 hydrogen bond · protein-protein
- B–D · 253 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4GUZ · Structure of the arylamine N-acetyltransferase from Mycobacterium abscessus · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B1ME52
- Elsewhere: RCSB PDB 4GUZ · PDBe 4GUZ · UniProt B1ME52
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