MolNFT v1 · #9311 · protein
Different length peptides bind to HLA-AW68 similarly at their ends but bulge out in the middle
1HSB · Class I histocompatibility antigen (HLA-AW68.1): “Different length peptides bind to HLA-AW68 similarly at their ends but bulge out in the middle”. X-ray diffraction, 4 pockets (best druggability 0.67). MolNFT v1 #9311 on GenesisL1…
- PDB
- 1HSB
- Type
- protein
- Length
- 374 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Class I histocompatibility antigen (HLA-AW68.1); Beta 2-microglobulin; Bound peptide…
- UniProt
- P01891, P01884
- Pockets
- 4 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Class I histocompatibility antigen (HLA-AW68.1) | protein | 272 | 26% helix, 39% strand | P01891 |
| B | Beta 2-microglobulin | protein | 99 | 0% helix, 49% strand | P01884 |
| C | Bound peptide fragment | protein | 3 | 0% helix, 0% strand | — |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 600 | 0.67 | 0.77 | 56 | empty |
| 2 | 132 | 0.44 | 0.76 | 17 | empty |
| 3 | 63 | 0.43 | 0.82 | 16 | empty |
| 4 | 70 | 0.34 | 0.76 | 15 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1303 Ų buried · 26 hydrogen bonds · protein-protein
- A–C · 286 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 1HSB · Different length peptides bind to HLA-AW68 similarly at their ends but bulge out in the… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01891
- Every structure of UniProt P01884
- Elsewhere: RCSB PDB 1HSB · PDBe 1HSB · UniProt P01891 · UniProt P01884
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