MolNFT v1 · #92742 · protein
Crystal structure of TRAF3/CARDIF
4GHU · TNF receptor-associated factor 3: “Crystal structure of TRAF3/CARDIF”. X-ray diffraction, 1 pocket (best druggability 0.29). MolNFT v1 #92742 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4GHU
- Type
- protein
- Length
- 204 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TNF receptor-associated factor 3; Mitochondrial antiviral-signaling protein
- UniProt
- Q60803, Q8VCF0
- Pockets
- 1 · best druggability 0.29
Structure
x-ray diffraction · 2 distinct chains · 28% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TNF receptor-associated factor 3 | protein | 190 | 30% helix, 28% strand | Q60803 |
| B | Mitochondrial antiviral-signaling protein | protein | 14 | 0% helix, 14% strand | Q8VCF0 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 76 | 0.29 | 0.72 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 788 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4GHU · Crystal structure of TRAF3/Cardif · the same entry in another collection · chain A against A, TM-score 1.00
- Q60803 · AlphaFold monomer V2.0 prediction for TNF receptor-associated factor 3 (Q60803) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q8VCF0 · AlphaFold monomer V2.0 prediction for mitochondrial antiviral- signaling protein (Q8VCF0) · a predicted model of the same protein · chain B against A, TM-score 0.25
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q60803
- Every structure of UniProt Q8VCF0
- Elsewhere: RCSB PDB 4GHU · PDBe 4GHU · UniProt Q60803 · UniProt Q8VCF0
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.