MolNFT v1 · #9273 · RNA

Crystal structure analysis of a mutant P4-P6 domain (DELC209) of tetrahymena themophila group I intron.

1HR2 · P4-P6 DELC209 mutant RNA ribozyme domain: “Crystal structure analysis of a mutant P4-P6 domain (DELC209) of tetrahymena themophila group I intron.”. X-ray diffraction, 1 ligand (MG), 10 pockets (best druggability 0.84). MolNFT v1…

PDB: 1HR2
Type: RNA
Length: 315 nucleotides
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: P4-P6 DELC209 mutant RNA ribozyme domain
Ligands: MG
Pockets: 10 · best druggability 0.84

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	P4-P6 DELC209 mutant RNA ribozyme domain	rna	157	—	—
B	P4-P6 DELC209 mutant RNA ribozyme domain	rna	158	—	—

Ligands and binding sites

MG · Magnesium ion · metal · 42 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

10 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1052	0.84	0.86	76	MG
2	391	0.70	0.83	43	MG
3	383	0.60	0.77	28	MG
4	606	0.59	0.73	33	MG
5	487	0.57	0.74	26	MG

Interfaces

1 interface between chains.

A–B · 998 Å² buried · 31 hydrogen bonds · nucleic-nucleic

Compared structures

1HR2 · Crystal structure analysis of a mutant P4-P6 domain (DELC209) of tetrahymena themophila… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1HR2 · PDBe 1HR2

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