MolNFT v1 · #92681 · protein
PTPN18 in complex with HER2-PY1248 phosphor-peptides
4GFU · Tyrosine-protein phosphatase non-receptor type 18: “PTPN18 in complex with HER2-PY1248 phosphor-peptides”. X-ray diffraction, 2 pockets (best druggability 0.49). MolNFT v1 #92681 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 4GFU
- Type
- protein
- Length
- 275 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 18; HER2-PY1248 phosphor-peptide
- EC
- 3.1.3.48
- UniProt
- Q99952
- Pockets
- 2 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) | protein | 268 | 37% helix, 21% strand | Q99952 |
| F | HER2-PY1248 phosphor-peptide | protein | 7 | 0% helix, 0% strand | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 169 | 0.49 | 0.77 | 19 | empty |
| 2 | 54 | 0.34 | 0.78 | 16 | empty |
Interfaces
1 interface between chains.
- A–F · 517 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 4GFU · PTPN18 in complex with HER2-pY1248 phosphor-peptides · the same entry in another collection · chain A against A, TM-score 1.00
- Q99952 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 18… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99952
- Elsewhere: RCSB PDB 4GFU · PDBe 4GFU · UniProt Q99952
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.