MolNFT v1 · #92663 · protein
N-terminal coiled-coil dimer of C.ELEGANS sas-6, crystal form a
4GFA · Spindle assembly abnormal protein 6: “N-terminal coiled-coil dimer of C.ELEGANS sas-6, crystal form a”. X-ray diffraction, 2 pockets (best druggability 0.36). MolNFT v1 #92663 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 4GFA
- Type
- protein
- Length
- 609 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Spindle assembly abnormal protein 6
- UniProt
- O62479
- Pockets
- 2 · best druggability 0.36
Structure
x-ray diffraction · 3 distinct chains · 26% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Spindle assembly abnormal protein 6 | protein | 155 | 26% helix, 39% strand | O62479 |
| C | Spindle assembly abnormal protein 6 | protein | 153 | 26% helix, 42% strand | O62479 |
| D | Spindle assembly abnormal protein 6 | protein | 146 | 27% helix, 40% strand | O62479 |
Ligands and binding sites
- MPD · (4S)-2-methyl-2,4-pentanediol · additive · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 57 | 0.36 | 0.79 | 17 | empty |
| 2 | 75 | 0.34 | 0.75 | 19 | empty |
Interfaces
2 interfaces between chains.
- A–C · 763 Ų buried · 4 hydrogen bonds · protein-protein
- B–D · 746 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 4GFA · N-terminal coiled-coil dimer of C.elegans SAS-6, crystal form A · the same entry in another collection · chain A against A, TM-score 1.00
- O62479 · AlphaFold monomer V2.0 prediction for spindle assembly abnormal protein 6 (O62479) · a predicted model of the same protein · chain C against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O62479
- Elsewhere: RCSB PDB 4GFA · PDBe 4GFA · UniProt O62479
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