MolNFT v1 · #92634 · protein
Crystal structure of MST4 dimerization domain complex with PDCD10
4GEH · Programmed cell death protein 10: “Crystal structure of MST4 dimerization domain complex with PDCD10”. X-ray diffraction, 3 pockets (best druggability 0.60). MolNFT v1 #92634 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 4GEH
- Type
- protein
- Length
- 530 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Programmed cell death protein 10; SERINE/THREONINE-protein kinase MST4
- EC
- 2.7.11.1
- UniProt
- Q9BUL8, Q9P289
- Pockets
- 3 · best druggability 0.60
Structure
x-ray diffraction · 3 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Programmed cell death protein 10 | protein | 198 | 80% helix, 0% strand | Q9BUL8 |
| B | SERINE/THREONINE-protein kinase MST4 (EC 2.7.11.1) | protein | 65 | 77% helix, 0% strand | Q9P289 |
| D | SERINE/THREONINE-protein kinase MST4 (EC 2.7.11.1) | protein | 69 | 80% helix, 0% strand | Q9P289 |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 98 | 0.60 | 0.87 | 19 | empty |
| 2 | 108 | 0.57 | 0.84 | 19 | empty |
| 3 | 283 | 0.57 | 0.77 | 37 | empty |
Interfaces
3 interfaces between chains.
- C–D · 1672 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 1585 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 235 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 4GEH · Crystal structure of MST4 dimerization domain complex with PDCD10 · the same entry in another collection · chain D against D, TM-score 1.00
- Q9BUL8 · AlphaFold monomer V2.0 prediction for programmed cell death protein 10 (Q9BUL8) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q9P289 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase 26 (Q9P289) · a predicted model of the same protein · chain B against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BUL8
- Every structure of UniProt Q9P289
- Elsewhere: RCSB PDB 4GEH · PDBe 4GEH · UniProt Q9BUL8 · UniProt Q9P289
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