MolNFT v1 · #92567 · protein

Crystal structure of murine TFB1M

4GC5 · Dimethyladenosine transferase 1, mitochondrial: “Crystal structure of murine TFB1M”. X-ray diffraction, 1 pocket (best druggability 0.41). MolNFT v1 #92567 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4GC5
Type: protein
Length: 319 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dimethyladenosine transferase 1, mitochondrial
EC: 2.1.1.-
UniProt: Q8JZM0
Pockets: 1 · best druggability 0.41

Structure

x-ray diffraction · 1 distinct chain · 47% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Dimethyladenosine transferase 1, mitochondrial (EC 2.1.1.-)	protein	319	47% helix, 14% strand	Q8JZM0

Ligands and binding sites

ACT · Acetate ion · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	60	0.41	0.81	16	ACT

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

4GC5 · Crystal structure of murine TFB1M · the same entry in another collection · chain A against A, TM-score 1.00
Q8JZM0 · AlphaFold monomer V2.0 prediction for dimethyladenosine transferase 1, mitochondrial… · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8JZM0
Elsewhere: RCSB PDB 4GC5 · PDBe 4GC5 · UniProt Q8JZM0

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