MolNFT v1 · #92500 · protein + RNA
Lassa nucleoprotein with dsrna reveals novel mechanism for immune suppression
4G9Z · RNA (5'-R(P*GP*CP*CP*C)-3'): “Lassa nucleoprotein with dsrna reveals novel mechanism for immune suppression”. X-ray diffraction, 1 ligand (ZN), 4 pockets (best druggability 0.49). MolNFT v1 #92500 on GenesisL1: 3D structure, binding…
- PDB
- 4G9Z
- Type
- protein + RNA
- Length
- 213 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA (5'-R(P*GP*CP*CP*C)-3'); RNA (5'-R(P*GP*GP*GP*C)-3'); Nucleoprotein
- UniProt
- P13699
- Ligands
- ZN
- Pockets
- 4 · best druggability 0.49
Structure
x-ray diffraction · 3 distinct chains · 38% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | RNA (5'-R(P*GP*CP*CP*C)-3') | rna | 4 | — | — |
| F | RNA (5'-R(P*GP*GP*GP*C)-3') | rna | 4 | — | — |
| A | Nucleoprotein | protein | 205 | 38% helix, 19% strand | P13699 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 118 | 0.49 | 0.80 | 18 | empty |
| 2 | 102 | 0.42 | 0.77 | 17 | empty |
| 3 | 78 | 0.41 | 0.79 | 12 | empty |
| 4 | 53 | 0.29 | 0.75 | 15 | empty |
Interfaces
3 interfaces between chains.
- F–A · 419 Ų buried · 11 hydrogen bonds · protein-nucleic
- E–A · 233 Ų buried · 8 hydrogen bonds · protein-nucleic
- E–F · 193 Ų buried · 20 hydrogen bonds · nucleic-nucleic
Compared structures
- 4G9Z · Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression · the same entry in another collection · chain E against E, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13699
- Elsewhere: RCSB PDB 4G9Z · PDBe 4G9Z · UniProt P13699
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