MolNFT v1 · #92378 · protein
Potassium transporter peripheral membrane component (trka) from vibrio vulnificus
4G65 · Trk system potassium uptake protein trka: “Potassium transporter peripheral membrane component (trka) from vibrio vulnificus”. X-ray diffraction, 2 ligands (CL, SO4), 13 pockets (best druggability 0.75). MolNFT v1 #92378 on…
- PDB
- 4G65
- Type
- protein
- Length
- 917 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Trk system potassium uptake protein trka
- UniProt
- Q8DDE6
- Ligands
- CL, SO4
- Pockets
- 13 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Trk system potassium uptake protein trka | protein | 459 | 36% helix, 25% strand | Q8DDE6 |
| B | Trk system potassium uptake protein trka | protein | 458 | 35% helix, 26% strand | Q8DDE6 |
Ligands and binding sites
- CL · Chloride ion · ion · 14 copies · chains A, B
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
- PG4 · Tetraethylene glycol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 661 | 0.75 | 0.81 | 85 | empty |
| 2 | 305 | 0.63 | 0.80 | 42 | empty |
| 3 | 147 | 0.50 | 0.79 | 23 | CL |
| 4 | 206 | 0.49 | 0.76 | 39 | SO4 |
| 5 | 167 | 0.49 | 0.77 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 836 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 22 modified (engineered).
Compared structures
- 4G65 · Potassium transporter peripheral membrane component (trkA) from Vibrio vulnificus · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8DDE6
- Elsewhere: RCSB PDB 4G65 · PDBe 4G65 · UniProt Q8DDE6
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