MolNFT v1 · #92275 · protein
Crystal structure of the marburg virus GP2 ectodomain in its post- fusion conformation
4G2K · General control protein GCN4, envelope glycoprotein GP2…: “Crystal structure of the marburg virus GP2 ectodomain in its post- fusion conformation”. X-ray diffraction, 1 ligand (CL), 1 pocket (best druggability 0.51). MolNFT v1…
- PDB
- 4G2K
- Type
- protein
- Length
- 325 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- General control protein GCN4, envelope glycoprotein GP2 chimera
- UniProt
- P03069, P35254
- Ligands
- CL
- Pockets
- 1 · best druggability 0.51
Structure
x-ray diffraction · 3 distinct chains · 88% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | General control protein GCN4, envelope glycoprotein GP2 chimera | protein | 110 | 88% helix, 0% strand | P03069, P35254 |
| B | General control protein GCN4, envelope glycoprotein GP2 chimera | protein | 108 | 88% helix, 0% strand | P03069, P35254 |
| C | General control protein GCN4, envelope glycoprotein GP2 chimera | protein | 107 | 88% helix, 0% strand | P03069, P35254 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 53 | 0.51 | 0.87 | 14 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2191 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 2111 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 2083 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 4G2K · Crystal structure of the Marburg Virus GP2 ectodomain in its post-fusion conformation · the same entry in another collection · chain A against A, TM-score 1.00
- P03069 · AlphaFold monomer V2.0 prediction for general control transcription factor GCN4 (P03069) · a predicted model of the same protein · chain C against A, TM-score 0.51
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03069
- Every structure of UniProt P35254
- Elsewhere: RCSB PDB 4G2K · PDBe 4G2K · UniProt P03069 · UniProt P35254
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