MolNFT v1 · #92137 · protein

Crystal structure of a legionella phosphoinositide phosphatase, sidf

4FYE · Sidf, inhibitor of growth family, member 3: “Crystal structure of a legionella phosphoinositide phosphatase, sidf”. X-ray diffraction, 1 ligand (PO4), 9 pockets (best druggability 0.82). MolNFT v1 #92137 on GenesisL1: 3D structure…

PDB: 4FYE
Type: protein
Length: 725 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sidf, inhibitor of growth family, member 3
EC: 3.1.3.67
UniProt: Q5ZSD5
Ligands: PO4
Pockets: 9 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 55% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sidf, inhibitor of growth family, member 3 (EC 3.1.3.67)	protein	725	55% helix, 12% strand	Q5ZSD5

Ligands and binding sites

PO4 · Phosphate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1079	0.82	0.83	104	PO4
2	442	0.62	0.76	41	empty
3	123	0.52	0.81	26	empty
4	153	0.49	0.79	28	empty
5	102	0.38	0.75	17	empty

Compared structures

4FYE · Crystal structure of a Legionella phosphoinositide phosphatase, SidF · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5ZSD5
Elsewhere: RCSB PDB 4FYE · PDBe 4FYE · UniProt Q5ZSD5

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