MolNFT v1 · #92134 · protein
Structural and functional characterizations of a thioredoxin-fold protein from helicobacter pylori
4FYB · THIOL:DISULFIDE interchange protein (dsbc): “Structural and functional characterizations of a thioredoxin-fold protein from helicobacter pylori”. X-ray diffraction, 1 pocket (best druggability 0.58). MolNFT v1 #92134 on GenesisL1…
- PDB
- 4FYB
- Type
- protein
- Length
- 323 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- THIOL:DISULFIDE interchange protein (dsbc)
- UniProt
- O25140
- Pockets
- 1 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | THIOL:DISULFIDE interchange protein (dsbc) | protein | 162 | 41% helix, 24% strand | O25140 |
| A | THIOL:DISULFIDE interchange protein (dsbc) | protein | 161 | 36% helix, 24% strand | O25140 |
Ligands and binding sites
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 436 | 0.58 | 0.75 | 48 | empty |
Interfaces
1 interface between chains.
- B–A · 149 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4FYB · Structural and functional characterizations of a thioredoxin-fold protein from… · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O25140
- Elsewhere: RCSB PDB 4FYB · PDBe 4FYB · UniProt O25140
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