MolNFT v1 · #91983 · protein + DNA
Crystal structure of NTRC4 DNA-binding domain bound to double-stranded DNA
4FTH · Transcriptional regulator (ntrc family): “Crystal structure of NTRC4 DNA-binding domain bound to double-stranded DNA”. X-ray diffraction, 3 pockets (best druggability 0.69). MolNFT v1 #91983 on GenesisL1: 3D structure, binding sites…
- PDB
- 4FTH
- Type
- protein + DNA
- Length
- 171 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional regulator (ntrc family); 5'-D(*AP*CP*TP*TP*GP*CP*AP*AP*AP*TP*TP*TP*GP*CP*A…
- UniProt
- O66551
- Pockets
- 3 · best druggability 0.69
Structure
x-ray diffraction · 4 distinct chains · 57% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional regulator (ntrc family) | protein | 68 | 53% helix, 0% strand | O66551 |
| B | Transcriptional regulator (ntrc family) | protein | 61 | 61% helix, 0% strand | O66551 |
| C | 5'-D(*AP*CP*TP*TP*GP*CP*AP*AP*AP*TP*TP*TP*GP*CP*AP*AP*AP*TP *GP*CP*AP*T)-3' | dna | 21 | — | — |
| D | 5'-D(P*GP*AP*TP*GP*CP*AP*TP*TP*TP*GP*CP*AP*AP*AP*TP*TP*TP*G P*CP*AP*A)-3' | dna | 21 | — | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 560 | 0.69 | 0.79 | 35 | empty |
| 2 | 94 | 0.34 | 0.73 | 18 | empty |
| 3 | 57 | 0.24 | 0.72 | 13 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1233 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 897 Ų buried · 93 hydrogen bonds · nucleic-nucleic
- A–D · 349 Ų buried · 4 hydrogen bonds · protein-nucleic
- B–C · 295 Ų buried · 1 hydrogen bond · protein-nucleic
- B–D · 259 Ų buried · 7 hydrogen bonds · protein-nucleic
Compared structures
- 4FTH · Crystal Structure of NtrC4 DNA-binding domain bound to double-stranded DNA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O66551
- Elsewhere: RCSB PDB 4FTH · PDBe 4FTH · UniProt O66551
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