MolNFT v1 · #91801 · protein
Crystal structure of lincosamide antibiotic adenylyltransferase lnua, apo
4FO1 · Lincosamide resistance protein: “Crystal structure of lincosamide antibiotic adenylyltransferase lnua, apo”. X-ray diffraction, 2 pockets (best druggability 0.48). MolNFT v1 #91801 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4FO1
- Type
- protein
- Length
- 316 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lincosamide resistance protein
- UniProt
- P06107
- Pockets
- 2 · best druggability 0.48
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Lincosamide resistance protein | protein | 158 | 36% helix, 32% strand | P06107 |
Ligands and binding sites
- EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 219 | 0.48 | 0.75 | 28 | EPE |
| 2 | 199 | 0.47 | 0.75 | 26 | EPE |
Interfaces
1 interface between chains.
- A–B · 109 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 4FO1 · Crystal structure of lincosamide antibiotic adenylyltransferase LnuA, apo · the same entry in another collection · chain A against A, TM-score 1.00
- P06107 · AlphaFold monomer V2.0 prediction for lincosamide resistance protein (P06107) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06107
- Elsewhere: RCSB PDB 4FO1 · PDBe 4FO1 · UniProt P06107
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