MolNFT v1 · #91795 · protein

Crystal structure of heparinase III

4FNV · Heparinase III protein, heparitin sulfate lyase: “Crystal structure of heparinase III”. X-ray diffraction, 4 pockets (best druggability 0.74). MolNFT v1 #91795 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4FNV
Type: protein
Length: 659 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heparinase III protein, heparitin sulfate lyase
UniProt: Q89YR9
Pockets: 4 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heparinase III protein, heparitin sulfate lyase	protein	659	34% helix, 24% strand	Q89YR9

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1139	0.74	0.77	81	empty
2	102	0.45	0.79	21	empty
3	105	0.40	0.76	22	empty
4	66	0.35	0.77	17	empty

Compared structures

4FNV · Crystal Structure of Heparinase III · the same entry in another collection · chain A against A, TM-score 1.00
Q89YR9 · AlphaFold monomer V2.0 prediction for heparin-sulfate lyase (Q89YR9) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q89YR9
Elsewhere: RCSB PDB 4FNV · PDBe 4FNV · UniProt Q89YR9

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