MolNFT v1 · #91628 · protein

Crystal structure of GLFT2

4FIX · Udp-galactofuranosyl transferase GLFT2: “Crystal structure of GLFT2”. X-ray diffraction, 1 ligand (MN), 12 pockets (best druggability 0.79). MolNFT v1 #91628 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4FIX
Type: protein
Length: 1,258 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Udp-galactofuranosyl transferase GLFT2
EC: 2.4.1.-
UniProt: O53585
Ligands: MN
Pockets: 12 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Udp-galactofuranosyl transferase GLFT2 (EC 2.4.1.-)	protein	629	38% helix, 24% strand	O53585

Ligands and binding sites

MN · Manganese (II) ion · metal · 2 copies · chains A, B
GOL · Glycerol · additive · 4 copies · chains A, B
BME · Beta-mercaptoethanol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	989	0.79	0.80	65	MN
2	1087	0.78	0.80	75	MN
3	918	0.72	0.76	84	empty
4	138	0.48	0.78	33	empty
5	125	0.45	0.77	16	empty

Interfaces

1 interface between chains.

A–B · 229 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

4FIX · Crystal Structure of GlfT2 · the same entry in another collection · chain A against A, TM-score 1.00
O53585 · AlphaFold monomer V2.0 prediction for galactofuranosyltransferase GLFT2 (O53585) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O53585
Elsewhere: RCSB PDB 4FIX · PDBe 4FIX · UniProt O53585

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