MolNFT v1 · #91559 · protein

Crystal structure of free CRM1 (crystal form 1)

4FGV · Chromosome region maintenance 1 (CRM1) or exportin 1 (XPO1): “Crystal structure of free CRM1 (crystal form 1)”. X-ray diffraction, 13 pockets (best druggability 0.63). MolNFT v1 #91559 on GenesisL1: 3D structure, binding sites and…

PDB: 4FGV
Type: protein
Length: 1,067 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chromosome region maintenance 1 (CRM1) or exportin 1 (XPO1)
Pockets: 13 · best druggability 0.63

Structure

x-ray diffraction · 1 distinct chain · 76% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Chromosome region maintenance 1 (CRM1) or exportin 1 (XPO1)	protein	1067	76% helix, 0% strand	—

Pockets

13 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	92	0.63	0.89	22	empty
2	282	0.58	0.78	45	empty
3	70	0.55	0.86	14	empty
4	186	0.46	0.75	34	empty
5	59	0.39	0.79	11	empty

Compared structures

4FGV · Crystal structure of free CRM1 (crystal form 1) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4FGV · PDBe 4FGV

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