MolNFT v1 · #91458 · protein

Kinetic and structural characterization of the 4-oxalocrotonate tautomerase isozymes from methylibium petroleiphilum

4FDX · 4-oxalocrotonase tautomerase isozyme: “Kinetic and structural characterization of the 4-oxalocrotonate tautomerase isozymes from methylibium…”. X-ray diffraction, 2 pockets (best druggability 0.41). MolNFT v1 #91458 on GenesisL1: 3D…

PDB: 4FDX
Type: protein
Length: 125 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 4-oxalocrotonase tautomerase isozyme
EC: 5.3.2.2
UniProt: A2SL37
Pockets: 2 · best druggability 0.41

Structure

x-ray diffraction · 2 distinct chains · 46% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	4-oxalocrotonase tautomerase isozyme (EC 5.3.2.2)	protein	61	43% helix, 30% strand	A2SL37
B	4-oxalocrotonase tautomerase isozyme (EC 5.3.2.2)	protein	64	50% helix, 28% strand	A2SL37

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	94	0.41	0.78	16	empty
2	77	0.37	0.76	13	empty

Interfaces

1 interface between chains.

A–B · 895 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

4FDX · Kinetic and structural characterization of the 4-oxalocrotonate tautomerase isozymes from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A2SL37
Elsewhere: RCSB PDB 4FDX · PDBe 4FDX · UniProt A2SL37

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