MolNFT v1 · #91427 · protein + DNA
Crystal structure of the bacteriophage mu transpososome
4FCY · Transposase: “Crystal structure of the bacteriophage mu transpososome”. X-ray diffraction, 20 pockets (best druggability 0.64). MolNFT v1 #91427 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4FCY
- Type
- protein + DNA
- Length
- 1,049 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transposase; DNA (68-mer); DNA (13-mer); DNA (49-mer)
- UniProt
- P07636
- Pockets
- 20 · best druggability 0.64
Structure
x-ray diffraction · 5 distinct chains · 45% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transposase | protein | 443 | 45% helix, 17% strand | P07636 |
| B | Transposase | protein | 476 | 44% helix, 17% strand | P07636 |
| C | DNA (68-mer) | dna | 68 | — | — |
| E | DNA (13-mer) | dna | 13 | — | — |
| D | DNA (49-mer) | dna | 49 | — | — |
Pockets
20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 363 | 0.64 | 0.79 | 37 | empty |
| 2 | 465 | 0.62 | 0.76 | 36 | empty |
| 3 | 160 | 0.58 | 0.82 | 22 | empty |
| 4 | 151 | 0.55 | 0.81 | 23 | empty |
| 5 | 322 | 0.54 | 0.75 | 33 | empty |
Interfaces
7 interfaces between chains.
- C–D · 2374 Ų buried · 227 hydrogen bonds · nucleic-nucleic
- A–B · 1685 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 778 Ų buried · 7 hydrogen bonds · protein-nucleic
- B–D · 719 Ų buried · 10 hydrogen bonds · protein-nucleic
- B–C · 660 Ų buried · 8 hydrogen bonds · protein-nucleic
Compared structures
- 4FCY · Crystal structure of the bacteriophage Mu transpososome · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07636
- Elsewhere: RCSB PDB 4FCY · PDBe 4FCY · UniProt P07636
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