MolNFT v1 · #91406 · protein
Glutamate dehydrogenase from E. COLI
4FCC: “Glutamate dehydrogenase from E. COLI”. X-ray diffraction, 20 pockets (best druggability 0.88). MolNFT v1 #91406 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4FCC
- Type
- protein
- Length
- 5,293 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate dehydrogenase
- UniProt
- Q8XDW9
- Pockets
- 20 · best druggability 0.88
Structure
x-ray diffraction · 3 distinct chains · 50% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D, E, F, G, I, J, K, L | Glutamate dehydrogenase | protein | 442 | 49% helix, 17% strand | Q8XDW9 |
| C | Glutamate dehydrogenase | protein | 435 | 50% helix, 17% strand | Q8XDW9 |
| H | Glutamate dehydrogenase | protein | 438 | 50% helix, 16% strand | Q8XDW9 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 987 | 0.88 | 0.89 | 145 | empty |
| 2 | 1046 | 0.87 | 0.88 | 142 | empty |
| 3 | 1052 | 0.87 | 0.88 | 135 | empty |
| 4 | 1194 | 0.85 | 0.86 | 142 | empty |
| 5 | 672 | 0.84 | 0.88 | 92 | empty |
Interfaces
28 interfaces between chains.
- J–L · 1573 Ų buried · 37 hydrogen bonds · protein-protein
- B–E · 1568 Ų buried · 35 hydrogen bonds · protein-protein
- H–K · 1557 Ų buried · 39 hydrogen bonds · protein-protein
- D–F · 1545 Ų buried · 38 hydrogen bonds · protein-protein
- A–C · 1544 Ų buried · 39 hydrogen bonds · protein-protein
Compared structures
- 4FCC · Glutamate dehydrogenase from E. coli · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8XDW9
- Elsewhere: RCSB PDB 4FCC · PDBe 4FCC · UniProt Q8XDW9
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