MolNFT v1 · #91369 · protein
Structure of mutant rip from barley seeds in complex with adenine (AMP-incubated)
4FBB · Protein synthesis inhibitor I: “Structure of mutant rip from barley seeds in complex with adenine (AMP-incubated)”. X-ray diffraction, 1 ligand (ADE), 19 pockets (best druggability 0.74). MolNFT v1 #91369 on GenesisL1: 3D structure…
- PDB
- 4FBB
- Type
- protein
- Length
- 1,112 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein synthesis inhibitor I
- EC
- 3.2.2.22
- UniProt
- P22244
- Ligands
- ADE
- Pockets
- 19 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Protein synthesis inhibitor I (EC 3.2.2.22) | protein | 278 | 40% helix, 15% strand | P22244 |
Ligands and binding sites
- ADE · Adenine · ligand · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
19 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 974 | 0.74 | 0.77 | 71 | empty |
| 2 | 960 | 0.72 | 0.76 | 76 | empty |
| 3 | 328 | 0.64 | 0.80 | 45 | empty |
| 4 | 255 | 0.60 | 0.80 | 38 | empty |
| 5 | 242 | 0.51 | 0.75 | 34 | empty |
Interfaces
5 interfaces between chains.
- A–B · 778 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 674 Ų buried · 11 hydrogen bonds · protein-protein
- A–D · 458 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 447 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 55 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4FBB · Structure of mutant RIP from barley seeds in complex with adenine (AMP-incubated) · the same entry in another collection · chain A against A, TM-score 1.00
- P22244 · AlphaFold monomer V2.0 prediction for protein synthesis inhibitor I (P22244) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22244
- Elsewhere: RCSB PDB 4FBB · PDBe 4FBB · UniProt P22244
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.