MolNFT v1 · #91366 · protein

Crystal structure of apo acyl-CoA carboxylase

4FB8 · Probable propionyl-CoA carboxylase beta chain 6: “Crystal structure of apo acyl-CoA carboxylase”. X-ray diffraction, 8 pockets (best druggability 0.88). MolNFT v1 #91366 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4FB8
Type: protein
Length: 862 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable propionyl-CoA carboxylase beta chain 6
EC: 6.4.1.3
UniProt: P63407
Pockets: 8 · best druggability 0.88

Structure

x-ray diffraction · 2 distinct chains · 33% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Probable propionyl-CoA carboxylase beta chain 6 (EC 6.4.1.3)	protein	435	32% helix, 13% strand	P63407
B	Probable propionyl-CoA carboxylase beta chain 6 (EC 6.4.1.3)	protein	427	33% helix, 14% strand	P63407

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	739	0.88	0.91	87	empty
2	405	0.73	0.83	52	empty
3	216	0.60	0.81	25	empty
4	197	0.50	0.77	30	empty
5	118	0.46	0.79	23	empty

Interfaces

1 interface between chains.

A–B · 2739 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

4FB8 · Crystal Structure of apo Acyl-CoA Carboxylase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P63407
Elsewhere: RCSB PDB 4FB8 · PDBe 4FB8 · UniProt P63407

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