MolNFT v1 · #91362 · protein + DNA
Polyomavirus T-ag binds symmetrical repeats at the viral origin in an asymmetrical manner
4FB3 · Ori DNA oligonucleotide-crick strand: “Polyomavirus T-ag binds symmetrical repeats at the viral origin in an asymmetrical manner”. X-ray diffraction, 5 pockets (best druggability 0.37). MolNFT v1 #91362 on GenesisL1: 3D structure…
- PDB
- 4FB3
- Type
- protein + DNA
- Length
- 395 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ori DNA oligonucleotide-crick strand; Ori DNA oligonucleotide-watson strand; Large T…
- EC
- 3.6.4.-
- UniProt
- P03074
- Pockets
- 5 · best druggability 0.37
Structure
x-ray diffraction · 4 distinct chains · 25% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Ori DNA oligonucleotide-crick strand | dna | 26 | — | — |
| W | Ori DNA oligonucleotide-watson strand | dna | 26 | — | — |
| A | Large T antigen (EC 3.6.4.-) | protein | 115 | 23% helix, 34% strand | P03074 |
| B, E | Large T antigen (EC 3.6.4.-) | protein | 114 | 26% helix, 35% strand | P03074 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 80 | 0.37 | 0.77 | 14 | empty |
| 2 | 68 | 0.37 | 0.78 | 14 | empty |
| 3 | 79 | 0.36 | 0.76 | 18 | empty |
| 4 | 100 | 0.33 | 0.73 | 17 | empty |
| 5 | 52 | 0.26 | 0.73 | 9 | empty |
Interfaces
8 interfaces between chains.
- C–W · 1150 Ų buried · 140 hydrogen bonds · nucleic-nucleic
- W–E · 415 Ų buried · 10 hydrogen bonds · protein-nucleic
- W–A · 412 Ų buried · 13 hydrogen bonds · protein-nucleic
- C–B · 379 Ų buried · 9 hydrogen bonds · protein-nucleic
- C–A · 353 Ų buried · 13 hydrogen bonds · protein-nucleic
Compared structures
- 4FB3 · Polyomavirus T-ag binds symmetrical repeats at the viral origin in an asymmetrical manner · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03074
- Elsewhere: RCSB PDB 4FB3 · PDBe 4FB3 · UniProt P03074
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