MolNFT v1 · #9131 · protein

X-ray structure of full-length annexin 1

1HM6: “X-ray structure of full-length annexin 1”. X-ray diffraction, 1 ligand (SO4), 8 pockets (best druggability 0.84). MolNFT v1 #9131 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1HM6
Type: protein
Length: 686 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Annexin 1
UniProt: P19619
Ligands: SO4
Pockets: 8 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 70% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Annexin 1	protein	343	70% helix, 1% strand	P19619

Ligands and binding sites

SO4 · Sulfate ion · ion · 12 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1167	0.84	0.85	104	empty
2	231	0.53	0.77	40	empty
3	110	0.52	0.82	21	empty
4	89	0.51	0.84	22	empty
5	210	0.51	0.76	40	empty

Interfaces

1 interface between chains.

A–B · 1543 Å² buried · 19 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1HM6 · X-ray structure of full-length annexin 1 · the same entry in another collection · chain A against A, TM-score 1.00
P19619 · AlphaFold monomer V2.0 prediction for annexin A1 (P19619) · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19619
Elsewhere: RCSB PDB 1HM6 · PDBe 1HM6 · UniProt P19619

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