MolNFT v1 · #9114 · protein + DNA
The crystal structure of an intact human max-DNA complex: new insights into mechanisms of transcriptional control
1HLO · DNA (5'-D(*CP*AP*CP*CP*AP*CP*GP*TP*GP*GP*T)-3'): “The crystal structure of an intact human max-DNA complex: new insights into mechanisms of transcriptional…”. X-ray diffraction, 2 pockets (best druggability 0.81). MolNFT v1 #9114 on…
- PDB
- 1HLO
- Type
- protein + DNA
- Length
- 175 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'-D(*CP*AP*CP*CP*AP*CP*GP*TP*GP*GP*T)-3'); DNA…
- UniProt
- P61244
- Pockets
- 2 · best druggability 0.81
Structure
x-ray diffraction · 4 distinct chains · 82% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | DNA (5'-D(*CP*AP*CP*CP*AP*CP*GP*TP*GP*GP*T)-3') | dna | 11 | — | — |
| D | DNA (5'-D(*AP*CP*CP*AP*CP*GP*TP*GP*GP*TP*G)-3') | dna | 11 | — | — |
| A | Protein (transcription factor max) | protein | 80 | 85% helix, 0% strand | P61244 |
| B | Protein (transcription factor max) | protein | 73 | 79% helix, 0% strand | P61244 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 188 | 0.81 | 0.96 | 24 | empty |
| 2 | 61 | 0.37 | 0.79 | 17 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1359 Ų buried · 21 hydrogen bonds · protein-protein
- C–D · 520 Ų buried · 51 hydrogen bonds · nucleic-nucleic
- D–B · 518 Ų buried · 13 hydrogen bonds · protein-nucleic
- C–A · 494 Ų buried · 15 hydrogen bonds · protein-nucleic
- C–B · 285 Ų buried · 4 hydrogen bonds · protein-nucleic
Compared structures
- 1HLO · The crystal structure of an intact human max-DNA complex: new insights into mechanisms of… · the same entry in another collection · chain C against C, TM-score 1.00
- P61244 · AlphaFold monomer V2.0 prediction for protein max (P61244) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61244
- Elsewhere: RCSB PDB 1HLO · PDBe 1HLO · UniProt P61244
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