MolNFT v1 · #91127 · protein + DNA

Protelomerase tela mutant R255A complexed with cttg hairpin DNA

4F41: “Protelomerase tela mutant R255A complexed with cttg hairpin DNA”. X-ray diffraction, 6 pockets (best druggability 0.73). MolNFT v1 #91127 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4F41
Type: protein + DNA
Length: 351 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protelomerase; DNA hairpin
UniProt: Q7CWV1
Pockets: 6 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 56% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protelomerase	protein	319	56% helix, 7% strand	Q7CWV1
C	DNA hairpin	dna	32	—	—

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	474	0.73	0.83	43	empty
2	336	0.69	0.83	46	empty
3	56	0.39	0.81	15	empty
4	63	0.39	0.79	12	empty
5	60	0.28	0.73	13	empty

Interfaces

1 interface between chains.

A–C · 2477 Å² buried · 47 hydrogen bonds · protein-nucleic

Compared structures

4F41 · Protelomerase TelA mutant R255A complexed with CTTG hairpin DNA · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7CWV1
Elsewhere: RCSB PDB 4F41 · PDBe 4F41 · UniProt Q7CWV1

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