MolNFT v1 · #9102 · protein
Crystal structure of thermotoga maritima alpha-fucosidase
1HL8 · Putative alpha-L-fucosidase: “Crystal structure of thermotoga maritima alpha-fucosidase”. X-ray diffraction, 4 pockets (best druggability 0.53). MolNFT v1 #9102 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1HL8
- Type
- protein
- Length
- 848 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative alpha-L-fucosidase
- EC
- 3.2.1.51
- UniProt
- Q9WYE2
- Pockets
- 4 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative alpha-L-fucosidase (EC 3.2.1.51) | protein | 426 | 32% helix, 20% strand | Q9WYE2 |
| B | Putative alpha-L-fucosidase (EC 3.2.1.51) | protein | 422 | 32% helix, 19% strand | Q9WYE2 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 181 | 0.53 | 0.78 | 21 | empty |
| 2 | 135 | 0.51 | 0.79 | 19 | empty |
| 3 | 66 | 0.30 | 0.74 | 15 | empty |
| 4 | 51 | 0.26 | 0.73 | 11 | empty |
Modifications
Observed in the structure: 2 disulfide, 2 modified (disulfide, carboxylation).
Compared structures
- 1HL8 · Crystal structure of thermotoga maritima alpha-fucosidase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WYE2
- Elsewhere: RCSB PDB 1HL8 · PDBe 1HL8 · UniProt Q9WYE2
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