MolNFT v1 · #91011 · protein
Crystal structure of an adenosine deaminase homolog from chromobacterium violaceum (target nysgrc-019589) with bound inosine.
4F0S · 5-METHYLTHIOADENOSINE/S-adenosylhomocysteine deaminase: “Crystal structure of an adenosine deaminase homolog from chromobacterium violaceum (target nysgrc-019589)…”. X-ray diffraction, 2 ligands (NOS, CL), 3 pockets (best…
- PDB
- 4F0S
- Type
- protein
- Length
- 434 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5-METHYLTHIOADENOSINE/S-adenosylhomocysteine deaminase
- EC
- 3.5.4.28, 3.5.4.31
- UniProt
- Q7NZ90
- Ligands
- NOS, CL
- Pockets
- 3 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 5-METHYLTHIOADENOSINE/S-adenosylhomocysteine deaminase (EC 3.5.4.28, 3.5.4.31) | protein | 434 | 43% helix, 24% strand | Q7NZ90 |
Ligands and binding sites
- NOS · Inosine · ligand · 2 copies · chains A
- CL · Chloride ion · ion · chains A
- PG4 · Tetraethylene glycol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 64 | 0.74 | 0.98 | 22 | NOS |
| 2 | 75 | 0.38 | 0.78 | 14 | empty |
| 3 | 110 | 0.38 | 0.75 | 23 | empty |
Modifications
Observed in the structure: 15 modified (engineered).
Compared structures
- 4F0S · Crystal structure of an adenosine deaminase homolog from Chromobacterium violaceum… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7NZ90
- Elsewhere: RCSB PDB 4F0S · PDBe 4F0S · UniProt Q7NZ90
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