MolNFT v1 · #90948 · protein
Crystal structure of an uncommon cellulosome-related protein module from ruminococcus flavefaciens that resembles papain-like cysteine peptidases
4EYZ: “Crystal structure of an uncommon cellulosome-related protein module from ruminococcus flavefaciens that…”. X-ray diffraction, 4 pockets (best druggability 0.54). MolNFT v1 #90948 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 4EYZ
- Type
- protein
- Length
- 492 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cellulosome-related protein module from ruminococcus flavefaciens that resembles…
- Pockets
- 4 · best druggability 0.54
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Cellulosome-related protein module from ruminococcus flavefaciens that resembles papain-like cysteine peptidases | protein | 246 | 30% helix, 18% strand | — |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 245 | 0.54 | 0.77 | 26 | empty |
| 2 | 238 | 0.54 | 0.77 | 26 | empty |
| 3 | 80 | 0.44 | 0.80 | 23 | empty |
| 4 | 64 | 0.42 | 0.81 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 599 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 modified (engineered, nonstandard).
Compared structures
- 4EYZ · Crystal structure of an uncommon cellulosome-related protein module from Ruminococcus… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4EYZ · PDBe 4EYZ
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