MolNFT v1 · #9091 · protein
CTBP/BARS: a dual-function protein involved in transcription corepression and golgi membrane fission
1HKU · C-terminal binding protein 3: “CTBP/BARS: a dual-function protein involved in transcription corepression and golgi membrane fission”. X-ray diffraction, 1 ligand (NAD), 2 pockets (best druggability 0.71). MolNFT v1 #9091 on…
- PDB
- 1HKU
- Type
- protein
- Length
- 331 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- C-terminal binding protein 3
- UniProt
- Q9Z2F5
- Ligands
- NAD
- Pockets
- 2 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | C-terminal binding protein 3 | protein | 331 | 36% helix, 17% strand | Q9Z2F5 |
Ligands and binding sites
- NAD · Nicotinamide-adenine-dinucleotide · ligand · chains A
- FMT · Formic acid · additive · 2 copies · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 494 | 0.71 | 0.81 | 62 | NAD, FMT |
| 2 | 97 | 0.40 | 0.77 | 16 | empty |
Modifications
Observed in the structure: 1 modified (oxidation).
Compared structures
- 1HKU · CtBP/BARS: a dual-function protein involved in transcription corepression and Golgi… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Z2F5 · AlphaFold monomer V2.0 prediction for C-terminal-binding protein 1 (Q9Z2F5) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Z2F5
- Elsewhere: RCSB PDB 1HKU · PDBe 1HKU · UniProt Q9Z2F5
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