MolNFT v1 · #90861 · protein

C-terminal domain of inner membrane protein cigr from salmonella enterica.

4EW5 · Cigr protein: “C-terminal domain of inner membrane protein cigr from salmonella enterica.”. X-ray diffraction, 1 pocket (best druggability 0.47). MolNFT v1 #90861 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4EW5
Type: protein
Length: 199 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cigr protein
UniProt: Q9Z621
Pockets: 1 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 22% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cigr protein	protein	102	20% helix, 22% strand	Q9Z621
B	Cigr protein	protein	97	25% helix, 23% strand	Q9Z621

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	152	0.47	0.76	27	empty

Interfaces

1 interface between chains.

A–B · 1104 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (engineered).

Compared structures

4EW5 · C-terminal domain of inner membrane protein CigR from Salmonella enterica. · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Z621
Elsewhere: RCSB PDB 4EW5 · PDBe 4EW5 · UniProt Q9Z621

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