MolNFT v1 · #90815 · protein

Structure of ATU4243-GABA sensor

4EUO · ABC transporter, substrate binding protein (polyamine): “Structure of ATU4243-GABA sensor”. X-ray diffraction, 2 ligands (ABU, SO4), 3 pockets (best druggability 0.37). MolNFT v1 #90815 on GenesisL1: 3D structure, binding sites and…

PDB: 4EUO
Type: protein
Length: 313 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ABC transporter, substrate binding protein (polyamine)
UniProt: A9CGA5
Ligands: ABU, SO4
Pockets: 3 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ABC transporter, substrate binding protein (polyamine)	protein	313	45% helix, 20% strand	A9CGA5

Ligands and binding sites

ABU · Gamma-amino-butanoic acid · ligand · chains A
SO4 · Sulfate ion · ion · chains A
GOL · Glycerol · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	88	0.37	0.76	21	GOL
2	85	0.36	0.76	17	empty
3	56	0.35	0.79	18	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

4EUO · Structure of Atu4243-GABA sensor · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A9CGA5
Elsewhere: RCSB PDB 4EUO · PDBe 4EUO · UniProt A9CGA5

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