MolNFT v1 · #90811 · protein
Crystal structure
4EUK · Histidine kinase 5: “Crystal structure”. X-ray diffraction, 1 ligand (MG), 3 pockets (best druggability 0.51). MolNFT v1 #90811 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4EUK
- Type
- protein
- Length
- 288 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histidine kinase 5; Histidine-containing phosphotransfer protein 1
- EC
- 2.7.13.3
- UniProt
- Q3S4A7, Q9ZNV9
- Ligands
- MG
- Pockets
- 3 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 63% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histidine kinase 5 (EC 2.7.13.3) | protein | 136 | 46% helix, 15% strand | Q3S4A7 |
| B | Histidine-containing phosphotransfer protein 1 | protein | 152 | 78% helix, 0% strand | Q9ZNV9 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 70 | 0.51 | 0.86 | 21 | MG |
| 2 | 157 | 0.48 | 0.77 | 24 | empty |
| 3 | 51 | 0.23 | 0.72 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 834 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 4EUK · Crystal structure · the same entry in another collection · chain A against A, TM-score 1.00
- Q3S4A7 · AlphaFold monomer V2.0 prediction for histidine kinase 5 (Q3S4A7) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q9ZNV9 · AlphaFold monomer V2.0 prediction for histidine-containing phosphotransfer protein 1… · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3S4A7
- Every structure of UniProt Q9ZNV9
- Elsewhere: RCSB PDB 4EUK · PDBe 4EUK · UniProt Q3S4A7 · UniProt Q9ZNV9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.