MolNFT v1 · #90764 · protein
Crystal structure of circularly permuted human asparaginase-like protein 1
4ET0 · L-asparaginase: “Crystal structure of circularly permuted human asparaginase-like protein 1”. X-ray diffraction, 1 ligand (NA), 2 pockets (best druggability 0.65). MolNFT v1 #90764 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4ET0
- Type
- protein
- Length
- 593 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- L-asparaginase
- EC
- 3.5.1.1
- UniProt
- Q7L266
- Ligands
- NA
- Pockets
- 2 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | L-asparaginase (EC 3.5.1.1) | protein | 295 | 36% helix, 25% strand | Q7L266 |
| B | L-asparaginase (EC 3.5.1.1) | protein | 298 | 36% helix, 25% strand | Q7L266 |
Ligands and binding sites
- NA · Sodium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 275 | 0.65 | 0.82 | 40 | empty |
| 2 | 238 | 0.57 | 0.79 | 37 | empty |
Interfaces
1 interface between chains.
- A–B · 1891 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
- 4ET0 · Crystal structure of circularly permuted human asparaginase-like protein 1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q7L266 · AlphaFold monomer V2.0 prediction for isoaspartyl PEPTIDASE/L-asparaginase (Q7L266) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7L266
- Elsewhere: RCSB PDB 4ET0 · PDBe 4ET0 · UniProt Q7L266
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