MolNFT v1 · #90738 · protein

Crystal structure of hemd (PA5259) from pseudomonas aeruginosa (PAO1) at 2.22 a resolution

4ES6 · Uroporphyrinogen-III synthase: “Crystal structure of hemd (PA5259) from pseudomonas aeruginosa (PAO1) at 2.22 a resolution”. X-ray diffraction, 1 ligand (CL), 1 pocket (best druggability 0.80). MolNFT v1 #90738 on GenesisL1: 3D…

PDB: 4ES6
Type: protein
Length: 249 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uroporphyrinogen-III synthase
EC: 4.2.1.75
UniProt: P48246
Ligands: CL
Pockets: 1 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uroporphyrinogen-III synthase (EC 4.2.1.75)	protein	249	45% helix, 19% strand	P48246

Ligands and binding sites

CL · Chloride ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	452	0.80	0.88	53	empty

Compared structures

4ES6 · Crystal structure of HemD (PA5259) from Pseudomonas aeruginosa (PAO1) at 2.22 A resolution · the same entry in another collection · chain A against A, TM-score 1.00
P48246 · AlphaFold monomer V2.0 prediction for uroporphyrinogen-III synthase (P48246) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P48246
Elsewhere: RCSB PDB 4ES6 · PDBe 4ES6 · UniProt P48246

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