MolNFT v1 · #90709 · protein + RNA
Crystal structure of the C-terminal domain of tetrahymena telomerase protein P65 in complex with stem IV of telomerase RNA
4ERD · Telomerase associated protein P65: “Crystal structure of the C-terminal domain of tetrahymena telomerase protein P65 in complex with stem IV of…”. X-ray diffraction, 1 ligand (K), 2 pockets (best druggability 0.70). MolNFT v1 #90709…
- PDB
- 4ERD
- Type
- protein + RNA
- Length
- 260 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Telomerase associated protein P65; 5'-R(P*GP*GP*UP*CP*GP*AP*CP*AP*UP*CP*UP*UP*CP*GP*GP*AP*…
- UniProt
- Q6JXI6
- Ligands
- K
- Pockets
- 2 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Telomerase associated protein P65 | protein | 108 | 44% helix, 28% strand | Q6JXI6 |
| C, D | 5'-R(P*GP*GP*UP*CP*GP*AP*CP*AP*UP*CP*UP*UP*CP*GP*GP*AP*UP*G P*GP*AP*CP*C)-3' | rna | 22 | — | — |
Ligands and binding sites
- K · Potassium ion · metal · chains A, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 811 | 0.70 | 0.77 | 52 | empty |
| 2 | 93 | 0.42 | 0.78 | 11 | empty |
Interfaces
5 interfaces between chains.
- C–D · 1047 Ų buried · 94 hydrogen bonds · nucleic-nucleic
- A–D · 540 Ų buried · 12 hydrogen bonds · protein-nucleic
- B–C · 535 Ų buried · 17 hydrogen bonds · protein-nucleic
- B–D · 358 Ų buried · 2 hydrogen bonds · protein-nucleic
- A–C · 323 Ų buried · 2 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 4ERD · Crystal structure of the C-terminal domain of Tetrahymena telomerase protein p65 in… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6JXI6
- Elsewhere: RCSB PDB 4ERD · PDBe 4ERD · UniProt Q6JXI6
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