MolNFT v1 · #9057 · protein
Structure of two fungal beta-1,4-galactanases: searching for the basis for temperature and pH optimum.
1HJS: “Structure of two fungal beta-1,4-galactanases: searching for the basis for temperature and pH optimum.”. X-ray diffraction, 2 ligands (NAG, SO4), 5 pockets (best druggability 0.53). MolNFT v1 #9057 on GenesisL1: 3D structure…
- PDB
- 1HJS
- Type
- protein
- Length
- 1,328 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-1,4-galactanase
- EC
- 3.2.1.89
- Ligands
- NAG, SO4
- Pockets
- 5 · best druggability 0.53
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Beta-1,4-galactanase (EC 3.2.1.89) | protein | 332 | 38% helix, 18% strand | — |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A, B, C, D
- SO4 · Sulfate ion · ion · 11 copies · chains A, B, C, D
- PEG · Di(hydroxyethyl)ether · additive · 13 copies · chains A, B, C, D
- EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 189 | 0.53 | 0.78 | 32 | empty |
| 2 | 191 | 0.52 | 0.78 | 31 | empty |
| 3 | 194 | 0.52 | 0.77 | 29 | empty |
| 4 | 180 | 0.50 | 0.77 | 30 | empty |
| 5 | 54 | 0.26 | 0.73 | 16 | empty |
Modifications
Observed in the structure: 4 disulfide, 4 glycan (disulfide, N-glycosylation).
Compared structures
- 1HJS · Structure of two fungal beta-1,4-galactanases: searching for the basis for temperature… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1HJS · PDBe 1HJS
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.