MolNFT v1 · #90542 · protein
Crystal structure of SPLSM4
4EMH · Probable U6 snrna-associated sm-like protein LSM4: “Crystal structure of SPLSM4”. X-ray diffraction, 15 pockets (best druggability 0.72). MolNFT v1 #90542 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4EMH
- Type
- protein
- Length
- 1,440 residues
- Chains
- 24
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable U6 snrna-associated sm-like protein LSM4
- UniProt
- O14352
- Pockets
- 15 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 5% helix, 65% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, T, U, V, W, X, Y | Probable U6 snrna-associated sm-like protein LSM4 | protein | 60 | 5% helix, 65% strand | O14352 |
Pockets
15 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 133 | 0.72 | 0.92 | 25 | empty |
| 2 | 144 | 0.71 | 0.90 | 26 | empty |
| 3 | 147 | 0.70 | 0.89 | 27 | empty |
| 4 | 131 | 0.70 | 0.90 | 23 | empty |
| 5 | 147 | 0.69 | 0.89 | 27 | empty |
Interfaces
28 interfaces between chains.
- B–E · 877 Ų buried · 18 hydrogen bonds · protein-protein
- J–M · 875 Ų buried · 9 hydrogen bonds · protein-protein
- U–V · 459 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 457 Ų buried · 7 hydrogen bonds · protein-protein
- M–O · 455 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 48 modified (engineered).
Compared structures
- 4EMH · Crystal structure of SpLsm4 · the same entry in another collection · chain D against D, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14352
- Elsewhere: RCSB PDB 4EMH · PDBe 4EMH · UniProt O14352
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