MolNFT v1 · #90265 · protein

Crystal structure of the novel phenazine prenyltransferase epzp (wildtype)

4EE8: “Crystal structure of the novel phenazine prenyltransferase epzp (wildtype)”. X-ray diffraction, 2 ligands (SO4, CL), 2 pockets (best druggability 0.83). MolNFT v1 #90265 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4EE8
Type: protein
Length: 300 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Prenyltransferase
UniProt: E5KWG9
Ligands: SO4, CL
Pockets: 2 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Prenyltransferase	protein	300	36% helix, 27% strand	E5KWG9

Ligands and binding sites

SO4 · Sulfate ion · ion · 7 copies · chains A
CL · Chloride ion · ion · chains A
ACT · Acetate ion · additive · chains A
EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	239	0.83	0.95	42	SO4
2	143	0.54	0.82	31	SO4

Compared structures

4EE8 · Crystal structure of the Novel Phenazine Prenyltransferase EpzP (wildtype) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E5KWG9
Elsewhere: RCSB PDB 4EE8 · PDBe 4EE8 · UniProt E5KWG9

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