MolNFT v1 · #90193 · protein
NTF2-like, potential transfer protein tram from gram-positive conjugative plasmid PIP501
4EC6 · Putative uncharacterized protein: “NTF2-like, potential transfer protein tram from gram-positive conjugative plasmid PIP501”. X-ray diffraction, 5 pockets (best druggability 0.65). MolNFT v1 #90193 on GenesisL1: 3D structure…
- PDB
- 4EC6
- Type
- protein
- Length
- 654 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative uncharacterized protein
- UniProt
- Q8L1C7
- Pockets
- 5 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 24% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Putative uncharacterized protein | protein | 109 | 24% helix, 39% strand | Q8L1C7 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 464 | 0.65 | 0.78 | 48 | empty |
| 2 | 410 | 0.63 | 0.78 | 45 | empty |
| 3 | 171 | 0.43 | 0.74 | 28 | empty |
| 4 | 106 | 0.36 | 0.74 | 16 | empty |
| 5 | 59 | 0.35 | 0.78 | 17 | empty |
Interfaces
7 interfaces between chains.
- E–F · 565 Ų buried · 9 hydrogen bonds · protein-protein
- D–E · 553 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 546 Ų buried · 5 hydrogen bonds · protein-protein
- D–F · 543 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 539 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 4EC6 · Ntf2-like, potential transfer protein TraM from Gram-positive conjugative plasmid pIP501 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8L1C7
- Elsewhere: RCSB PDB 4EC6 · PDBe 4EC6 · UniProt Q8L1C7
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