MolNFT v1 · #90060 · protein

Structure of GSK3 from ustilago maydis

4E7W · Glycogen synthase kinase 3: “Structure of GSK3 from ustilago maydis”. X-ray diffraction, 3 pockets (best druggability 0.58). MolNFT v1 #90060 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4E7W
Type: protein
Length: 360 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glycogen synthase kinase 3
EC: 2.7.11.1
UniProt: Q4PH53
Pockets: 3 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glycogen synthase kinase 3 (EC 2.7.11.1)	protein	360	35% helix, 19% strand	Q4PH53

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	301	0.58	0.77	38	empty
2	71	0.40	0.79	14	empty
3	54	0.33	0.77	12	empty

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

4E7W · Structure of GSK3 from Ustilago maydis · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4PH53
Elsewhere: RCSB PDB 4E7W · PDBe 4E7W · UniProt Q4PH53

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