MolNFT v1 · #89824 · protein
Crystal structure of mpn domain from COP9 signalosome
4E0Q · COP9 signalosome complex subunit 6: “Crystal structure of mpn domain from COP9 signalosome”. X-ray diffraction, 5 pockets (best druggability 0.46). MolNFT v1 #89824 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4E0Q
- Type
- protein
- Length
- 231 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- COP9 signalosome complex subunit 6
- UniProt
- Q9VCY3
- Pockets
- 5 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | COP9 signalosome complex subunit 6 | protein | 121 | 32% helix, 39% strand | Q9VCY3 |
| B | COP9 signalosome complex subunit 6 | protein | 110 | 31% helix, 37% strand | Q9VCY3 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 130 | 0.46 | 0.77 | 24 | empty |
| 2 | 64 | 0.44 | 0.82 | 16 | empty |
| 3 | 152 | 0.42 | 0.74 | 27 | empty |
| 4 | 97 | 0.36 | 0.74 | 19 | empty |
| 5 | 56 | 0.27 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1006 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9VCY3
- Elsewhere: RCSB PDB 4E0Q · PDBe 4E0Q · UniProt Q9VCY3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.