MolNFT v1 · #89759 · protein

Crystal structure of apo swine flu influenza nucleoprotein

4DYS · Nucleocapsid protein: “Crystal structure of apo swine flu influenza nucleoprotein”. X-ray diffraction, 14 pockets (best druggability 0.76). MolNFT v1 #89759 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4DYS
Type: protein
Length: 1,343 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleocapsid protein
UniProt: G8XKZ6
Pockets: 14 · best druggability 0.76

Structure

x-ray diffraction · 3 distinct chains · 47% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleocapsid protein	protein	441	50% helix, 9% strand	G8XKZ6
B	Nucleocapsid protein	protein	448	46% helix, 8% strand	G8XKZ6
C	Nucleocapsid protein	protein	454	46% helix, 9% strand	G8XKZ6

Pockets

14 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	897	0.76	0.79	109	empty
2	721	0.76	0.81	90	empty
3	60	0.52	0.88	20	empty
4	138	0.45	0.76	17	empty
5	118	0.43	0.77	19	empty

Interfaces

3 interfaces between chains.

B–C · 2246 Å² buried · 41 hydrogen bonds · protein-protein
A–C · 2177 Å² buried · 33 hydrogen bonds · protein-protein
A–B · 2074 Å² buried · 31 hydrogen bonds · protein-protein

Compared structures

4DYS · Crystal Structure of Apo Swine Flu Influenza Nucleoprotein · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G8XKZ6
Elsewhere: RCSB PDB 4DYS · PDBe 4DYS · UniProt G8XKZ6

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